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. Author manuscript; available in PMC: 2012 Sep 21.

Published in final edited form as: J Am Chem Soc. 2011 Aug 25;133(37):14492–14495. doi: 10.1021/ja204716f

CrpD-M2 biosynthetic scheme. (A) Enzymes used in this study, CrpD-M2 and Crp TE. Domains within the CrpD-M2 polypeptide are noted with squares, and the phosphopantetheinyl arm is denoted by the linked SH group. (B) Reactions catalyzed by CrpD-M2 and Crp TE mediated cyclization. (B) SNAC-ABC analogs utilized (3–5).⁸ (D) Cyclic cryptophycins (6–8),^11–13 and linear seco-cryptophycins (9–11) generated by CrpD-M2 and Crp TE⁸. , , , and .

Inline graphic — CrpD-M2 biosynthetic scheme. (A) Enzymes used in this study, CrpD-M2 and Crp TE. Domains within the CrpD-M2 polypeptide are noted with squares, and the phosphopantetheinyl arm is denoted by the linked SH group. (B) Reactions catalyzed by CrpD-M2 and Crp TE mediated cyclization. (B) SNAC-ABC analogs utilized (3–5).⁸ (D) Cyclic cryptophycins (6–8),^11–13 and linear seco-cryptophycins (9–11) generated by CrpD-M2 and Crp TE⁸. , , , and .