Table IV.
Descriptive statistics of key variables for two classifications.
| Old Groups: | Control | Far | Mid | Near | Statistic / p-value | Group Contrasts |
|---|---|---|---|---|---|---|
| New Groups: | Control | Low | Med | High | ||
| N (% of total) | 233 (24.20%) | 275 (28.56%) | 276 (28.66%) | 179 (18.59%) | - | - |
| 233 (24.20%) | 182 (18.90%) | 256 (26.58%) | 292 (30.32%) | - | ||
| Gender (% F) | 63.52 | 67.64 | 61.96 | 58.66 | Chi-sq = 4.11, p = 0.25 | ns |
| 63.52 | 67.03 | 65.23 | 59.25 | Chi-sq = 3.58, p = 0.31 | ns | |
| Age Mean (SD) | 43.48 (11.63) | 36.54 (8.13) | 42.17 (9.74) | 44.98 (10.16) | F = 29.36, p < 0.0001 | C, N, M > F |
| 43.48 (11.63) | 35.52 (7.49) | 41.77 (9.32) | 44.33 (9.76) | F = 33.93, p < 0.0001 | C, H > M > L | |
| CAG Mean (SD) | 20.01 (3.49) | 41.00 (1.57) | 42.55 (2.14) | 44.23 (3.05) | F = 4347.48, p < 0.0001 | C < F < M < N |
| 20.45 (3.49) | 40.76 (1.56) | 42.00 (1.99) | 43.72 (2.77) | F = 4271.10, p < 0.0001 | C < L < M < H | |
| Education Mean (SD) | 14.65 (2.66) | 14.55 (2.50) | 14.35 (2.80) | 14.16 (2.74) | F = 1.36, p = 0.25 | ns |
| 14.65 (2.66) | 14.52 (2.52) | 14.43 (2.68) | 14.24 (2.76) | F = 1.09, p = 0.35 | ns | |
| Striatal Volume Mean (SD)a | 15.99 (2.14) | 14.92 (2.19) | 12.99 (2.33) | 10.94 (2.45) | F = 150.93, p < 0.0001 | C > F > M > N |
| 15.99 (2.14) | 15.22 (2.15) | 13.69 (2.25) | 11.59 (2.52) | F = 142.91, p < 0.35 | C > L > M > H | |
| UHDRS Motor Score Mean (SD) | 2.65 (3.35) | 3.37 (3.73) | 4.71 (4.76) | 7.87 (6.81) | F = 48.69, p < 0.0001 | C, F < M < N |
| 2.65 (3.35) | 2.99 (3.33) | 4.29 (4.40) | 6.82 (6.35) | F = 41.70, p < 0.0001 | C, L < M < H | |
| Symbol Digit Mean (SD) | 54.03 (8.95) | 54.12 (11.30) | 49.25 (10.46) | 44.06 (11.05) | F = 49.28, p < 0.0001 | C, F > M > N |
| 54.03 (8.95) | 56.41 (11.44) | 51.20 (10.46) | 45.42 (10.93) | F = 50.33, p < 0.0001 | C, L > M > H | |
| HVLT Mean (SD) | 28.11 (4.43) | 27.76 (4.24) | 26.18 (5.13) | 23.84 (5.42) | F = 33.46, p < 0.0001 | C, F > M > N |
| 28.11 (4.43) | 28.03 (4.04) | 26.77 (4.95) | 24.56 (5.37) | F = 30.58, p < 0.0001 | C, L > M > H | |
| FrSBe Total Mean (SD) | 55.19 (12.90) | 59.79 (19.78) | 61.62 (19.87) | 57.09 (18.87) | F = 6.00, p = 0.0001 | M > C, N; F > C |
| 55.19 (12.90) | 59.42 (20.05) | 60.96 (19.76) | 59.07 (19.30) | F = 4.27, p = 0.0055 | C < M | |
| FrSBe Executive Mean (SD) | 24.59 (6.79) | 26.53 (10.00) | 27.47 (9.65) | 25.80 (9.54) | F = 4.40, p = 0.0044 | C < M |
| 24.59 (6.79) | 25.23 (9.98) | 26.89 (9.53) | 26.85 (9.86) | F = 3.36, p = 0.0183 | C < M, H | |
| SCOPI Mean (SD)b | 73.54 (18.91) | 76.66 (21.81) | 77.52 (21.30) | 71.01 (21.29) | F = 2.02, p = 0.1128 | ns |
| 73.54 (18.91) | 75.00 (21.39) | 79.30 (22.12) | 72.65 (20.88) | F = 2.34, p = 0.0724 | ns | |
Note.
a
Striatal Volume comparison is based on a sample size of N = 798 (Control = 192, Low = 163, Mid = 218, High = 225).
b
SCOPI comparison is based on a sample size of N = 546 (Control = 175, Low = 113, Mid = 130, High = 128).