Table 4.

Advantages, Disadvantages and Limitations of GLP-1, Agonists and its Analogues

	Advantages	Disadvantages	Limitations
GLP-1	Reduction of body weight by about 1.9% (in T2DM patients [107] Enhanced sense of fullness [108] Increase insulin secretion [109]	Gastrointestinal side effects [110] Expensive [110]	Can only be given subcutaneously [110]
Liraglutide (a GLP-1 analogue)	Action depends on glucose level Increases satiety Enhance regeneration of new beta cells Decreases plasma lipid level Long half life [37], [38]	Gastrointestinal side-effects	Can only be given subcutaneously Thyroid C-cell cancer risk [111] Cancer risk disputed in human [112]
Albiglutide (a GLP-1 analogue)	Very long half life (4-7 days) DPP-4 resistant Reduce fasting blood glucose [47, 48]	Skin rash at site of injection [47, 48]	Can only be given subcutaneously [110]