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. 2011 Sep 9;5:82–92. doi: 10.2174/1874104501105010082

Table 5a.

Advantages, Disadvantages and Limitations of Newer DPP-4 Inhibitors

Advantages Disadvantages Limitations
Vildagliptin

  • Can be used with metformin

  • Oral administration [81-89]

  • coronary artery disease

  • deep venous thrombosis

  • acute uveitis

  • renal calculus

  • skin lesion [113]

  • Risk of developing cancer [114]
Sitagliptin

  • Can be used with metformin

  • Oral administration

  • Lower occurrence of side effect [75-80]

  • Pancreatitis

  • Nausea

[115]

  • Risk of developing cancer [114]
Saxagliptin

  • Oral administration

  • Once daily

  • More effective when combined with other oral hypoglycemic agents [73-78]

  • headache

  • infections of upper respiratory & urinary tracts [116]

  • Leukopenia?

  • Metabolized by CYP 3A4 [117]

  • Risk of developing cancer [114]

  • Potential for drug interaction

[117]