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. Author manuscript; available in PMC: 2011 Sep 16.
Published in final edited form as: Immunol Lett. 2010 Jan 4;130(1-2):26–31. doi: 10.1016/j.imlet.2009.12.009

Figure 2. Consequences of dendritic cell migration out of chronic granulomas; dissemination and T cell priming.

Figure 2

A, DCs containing viable mycobacteria migrate out of chronic primary lesions. In cases of miliary TB, mycobacterial dissemination first reaches vascular organs liver, spleen bone marrow, and brain. However, dissemination may ultimately reach all organs of the body. B, Dissemination of viable bacilli or mycobacterial antigen from the granuloma to the draining lymph nodes within DCs. During acute infection this process is mediated by chemokine receptor 7, and possible 8 on DCs in response to ligands CCL19 and CCL21, and CCL1, respectively, expressed in the lymphatics and in the lymph nodes. Newly primed mycobacteria-specific T cells would migrate out of the lymph node to chronic lesions to maintain cellular immunity.