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. Author manuscript; available in PMC: 2011 Sep 16.
Published in final edited form as: Immunol Lett. 2010 Jan 4;130(1-2):26–31. doi: 10.1016/j.imlet.2009.12.009

Figure 3. DC – T cell cross talk within chronic granulomas.

Figure 3

A, DCs with stimulatory phenotype, high expression of MHCII, CD40, CD86, CD80, and secreting IL-12, are likely to support a Th1-IFNγ producing T cell phenotype. This DC phenotype will result in mycobacterial killing within macrophage through the secretion of IFNγ by T cells. B, DCs found within chronic granulomas with low expression of T cell stimulatory molecules and secreting IL-10, will be liable to support an anergic or regulatory T cell response. This would result in less local IFNγ production, and thus, maintain mycobacterial latency inside macrophage.