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(A) Perpendicular alignment between helices H2 and H25 in the T. Thermophilus 23S rRNA structure (PDB 2J01). Residues in blue correspond to the AGPM motif (G539-U554 and G17-C523) and residues in red correspond to the ribo-base interaction type I (C540-G553 and C18-G522). (B) Ribo-base interactions types I and II. (C) Consensus motif for the perpendicular interaction of helices composed of four stacked basepairs at each helix.
