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. 2011 Jun 8;301(3):F544–F553. doi: 10.1152/ajprenal.00709.2010

Fig. 11.

Fig. 11.

BAPTA-AM inhibits ATP-induced Isc in mIMCD-K2 cells. A: superimposed representative traces of Isc responses to apical and basal addition of 10−5 M ATP following treatment with control (solid trace) or BAPTA-AM (dashed trace). Am, 10−5 M amiloride (apical addition); BAPTA, 5 × 10−5 M BAPTA-AM (added to both sides); ATP(a) and ATP(b) indicate 10−5 M ATP added to the apical and basal baths, respectively. B: average Isc values in response to apical addition of ATP (ΔIscATP) in control filters (open bars) or in filters pretreated with BAPTA-AM (closed bars). Isc responses are categorized as transient or subsequent sustained responses. Values are means ± SE (n = 12 filters). C: average Isc values in response to basal addition of ATP in control filters (open bars) or in filters pretreated with BAPTA-AM (closed bars). Values are means ± SE (n = 12 filters). *, #Values significantly different from those in control cell sheets.