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. 2011 Jun 8;301(3):F544–F553. doi: 10.1152/ajprenal.00709.2010

Fig. 5.

Fig. 5.

Basal addition of BaCl2 to mIMCD-K2 cells inhibits ATP-induced Isc. A: superimposed representative traces of Isc responses to apical and basal addition of 10−5 M ATP following treatment with control (solid trace) or 5 × 10−3 M BaCl2 (dashed trace). Am, 10−5 M amiloride (apical addition); Ba2+, 5 × 10−3 M BaCl2 (basal addition); ATP(a) and ATP(b) indicate 10−5 M ATP added to the apical and basal baths, respectively. B: average Isc values in response to apical addition of ATP (ΔIscATP) in control cells (open bars) or in cells pretreated with BaCl2 to the basal side (closed bars). Isc responses are categorized as transient or subsequent sustained responses. Values are means ± SE (n = 12 filters). C: average Isc values in response to basal addition of ATP in control filters (open bars) or in filters pretreated with BaCl2 to the basal side (closed bars). Values are means ± SE (n = 12 filters). *Values significantly different from those in control cell sheets.