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Scheme of ERK pathway-mediated P2X7 expression in renal fibroblasts. Exposure of renal necrotic RPTC induces activation of the MEK1/ERK pathway, which in turn activates Elk1, a nuclear transcriptional factor. Activated Elk1 binds to P2X7 gene and drives its expression thereby increasing P2X7 protein levels on cell surface and it induces cell death in renal fibroblasts.
