Fig. 10.

Comparison of TRPA1- and TRPV1-mediated nociceptive behavior. A: latency of onset of nocifensive behavior was not significantly different for TRPV1 knockout mice injected with intraplantar AITC (1 mM) or wild-type mice injected with capsaicin (2 mM). B: total duration of nocifensive behavior after injection of AITC was significantly longer that of induced by capsaicin injection. C: mean number of hind paw licks after AITC injection was significantly higher than that induced by capsaicin injection. D: mean number of hind paw shakes after AITC injection was significantly higher than that observed with capsaicin injection. E: intrathecal administration of 25 μg/20 μl AITC induced a long-lasting thermal hypersensitivity as compared with intrathecal administration of capsaicin. F: intrathecal administration of 25 μg/20 μl AITC caused a long-lasting change in mechanical sensitivity, whereas intrathecal administration of capsaicin had no effect.