Fig. 8.

Modulation of miniature excitatory postsynaptic currents (mEPSCs) by activation of TRPA1 at the brain stem. A: application of AITC (300 μM) to a slice, where the caudal spinal trigeminal nucleus (CSTN) neuron is patch clamped at −60 mV, increased mEPSC frequency and amplitude. The mEPSCs are shown in an expanded time scale below. B: cumulative probability histogram for inter-event intervals. AITC significantly decreased the inter-event interval (KS test P < 0.05). C: cumulative probability histogram for amplitude. AITC significantly increased the amplitude (KS test, P < 0.05). D: summary graph showing the percent increase in mEPSC frequency.