Fig. 9.

Modulation of miniature inhibitory postsynaptic currents (mIPSCs) by activation of TRPA1 at the brain stem. A: application of AITC (100 μM) to a slice where the CSTN neuron is patch clamped at 0 mV, increased mIPSC frequency and amplitude. The recordings are shown in an expanded time scale below. B: cumulative probability histogram for inter-event interval. AITC significantly decreased the inter-event interval (KS test, P < 0.05). C: cumulative probability histogram for amplitude. AITC significantly increased amplitude (KS test, P < 0.05). D: summary graph showing the percent increase in mIPSC frequency.