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. 2011 Aug 29;108(37):15324–15329. doi: 10.1073/pnas.1100255108

Fig. 1.

Fig. 1.

Absence of the Nlrp3-inflammasome protects against the development of HFD-induced obesity. (A) qPCR analysis of caspase-1 gene expression levels in epididymal WAT of LFD- and HFD-fed wild-type C57/Bl6 animals after 16 wk of diet-intervention. (B) Caspase-1 protein levels in WAT of LFD- vs. HFD-fed wild-type animals. Comparison of bodyweight gain in wild-type, Nlrp3−/−(C), ASC−/− (D), and Casp1−/− (E) animals on LFD or HFD during 16 wk. (F) Daily food intake of wild-type, Nlrp3−/−, ASC−/−, and Casp1−/− animals fed a LFD or HFD. Plasma concentrations of insulin (G), leptin (H), and resistin (I) in LFD- and HFD-fed wild-type, Nlrp3−/−, ASC−/−, and Casp1−/− mice. **P < 0.01; ***P < 0.001; n = 6–8 mice per group. Error bars represent SEM.