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Mapping NP residues that influence inhibitor efficacy. Site-directed mutagenesis of NP and subsequent evaluation in the cell-based plasmid polymerase assay revealed two discontinuous regions of NP that are sensitive to amino acid substitution. Red, sensitive residues (more than threefold increase in IC50 compared with WT); green, tolerant residues (less than threefold change in IC50 compared with WT).
