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. 2011 Sep 1;108(37):15366–15371. doi: 10.1073/pnas.1107906108

Fig. 5.

Fig. 5.

Characterization of inhibitor efficacy in a mouse model of influenza infection. (A) Serum concentration–time curves for compound 5 in mice after a single 10 or 50 mg/kg i.p. dose. (B–D) Mouse cohorts were pretreated with vehicle, compound 5, or OC at 1 h before intranasal infection with 500 pfu of A/WSN influenza virus. Drug or vehicle treatment continued for 5 d. (B) Survival time-course graph. All but two cohorts (vehicle and 2 mg/kg compound 5 t.i.d.) showed 100% survival. (C) Daily body weight loss. (D) Viral titers at days 5 and 8 postinfection. Administration of compound 5 on a 10 mg/kg t.i.d. dosing regimen for 5 d reduced the viral titer below the limit of detection (500 pfu) on days 5 and 8.