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Heart rate and mean arterial pressure responses in fetal sheep to isocapnic hypoxia during intravascular infusion of an adenosine A2A receptor antagonist (ZM-241385) or vehicle. Vertical bars depict ± 1 SE. Horizontal bar shows time of hypoxia and infusion. *P < 0.05 compared with control at time 0; †P < 0.05 compared with vehicle at same time. During hypoxia, mean fetal PaO2 was ∼15 Torr (ΔPaO2, about −9 Torr compared with normoxia). [Modified from Koos and Maeda (186).]
