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Incidence of rapid eye movements and breathing during isocapnic hypoxia in normal fetal sheep with intravascular infusion of vehicle or ZM-241385. ZM-241385 blocked the inhibitory effects of hypoxia on breathing and rapid eye movements. During hypoxia, mean PaO2 was ∼14 Torr (ΔPaO2, about −10 Torr compared with normoxia). *P < 0.05 compared with normoxia. [Modified from Koos et al. (188).]
