Table 3.
Adenosine A2A signal transduction involving cAMP-dependent kinase*
| ↑ L-type Ca2+ channel |
| ↑ aPKC |
| ↑ CREB→↓NFkB |
| ↑ DARPP-32 |
| ↑ Rac1/Cdc42 → →→p38 |
| ↑ Src → Ras →Raf-1→MEK → ERK1/2 |
*
Via G protein activation of adenylyl cyclase and increase in intracellular cAMP.
aPKC, atypical protein kinase C; CREB, cAMP responsive element binding protein; NFkB, nuclear factor-кB; DARPP-32, dopamine- and cAMP-regulated neuronal phosphoprotein; p38, p38 mitogen-activated protein kinase; ERK1/2, extracellular signal-regulated kinases 1 and 2. [lsqb]Modified from Fredholm et al. (93).[rsqb]