Fig. 8.

Maintenance of neuronal phenotype in a primary neuron: suggested model. Molecules at the cell surface represent receptors and/or ligands, as indicated. Molecules underlined are upregulated, and molecules in italics are downregulated, in microarray analysis. Some major neuronal-specific functions and the upstream signals are involved in its maintenance. Growth factors are indicated in boldface type, since some are up- and some are downregulated (see Table 3). All other molecules are not changed on the microarray analysis. GF, growth factors; AF, axon formation; AG, axon guidance; AR, axon remodeling; AA, anti-apotptosis; PR, proliferation response; axon guid, axon guidance; LTP, long-term potentiation; SFA, stress fiber activation; GluR. glutamate receptor; AGC, attraction of growth cone.