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. 2011 Jun 15;301(3):R676–R681. doi: 10.1152/ajpregu.00176.2011

Fig. 1.

Fig. 1.

Central (intracerebroventricular) vs. peripheral (intravenous) effect of oxytocin (OT) to induce the prolactin (PRL) secretory rhythm. A: ovariectomized (OVX) rats were injected with OT (0.3 μg, n = 12) or vehicle (n = 7) intracerebroventricularly at 1600 of day 0 (arrow). B: OVX rats were injected intravenously with OT (5 μg) at 1600 of day 0 (arrow). In 13 rats, the OT antagonist (OTa, 9 μg/h) was infused intravenously beginning around 1200 of day 0 for 24 h. Blood samples were withdrawn during the next 2 days to observe the PRL diurnal and nocturnal surges. Data are presented as means ± SE. #P < 0.05 and ###P < 0.001 vs. control group at the same time. *P < 0.05, ***P < 0.001 vs. 0100 of day 2 PRL in the same experimental group.