Fig. 4.

Effect of dietary fat on the resolution of insulin and leptin and the energy gap at the maintenance-relapse transition. A: insulin and leptin, expressed as a percentage of obese controls, are shown for energy-restricted, weight-maintained rats before (weight reduced and in energy balance) and after the first day of relapse. Data were drawn from three similar DIO rat weight loss studies of relapse on diets containing 12%, 25%, and 40% kcal fat. B: energy gap at this transition from weight maintenance to relapse is estimated from the positive energy balance on the first day of relapse. [Data were adapted from Am J Physiol Regul Integr Comp Physiol 294: R1117–R1129, 2008 and two similar ongoing studies with higher levels of dietary fat (n = 6–10/group)]. *Significantly different from 12% kcal fat diet, P < 0.001.