Table 1.
Serum concentrations of androgens and other sexual steroids, body composition, and insulin sensitivity as assessed with OGTT, ITT, and hyperinsulinemic-euglycemic clamp in a 64-year-old Hispanic woman with Leydig cell tumor of the ovary before surgery and 1 month and 9 months after curative surgery
| Preoperatively | Postoperatively |
||
|---|---|---|---|
| 1 month | 9 months | ||
| Serum hormones | |||
| Androgens | |||
| Total testosterone (ng/dl; NR: 10–57) | 1,143 | 61 | 41 |
| Free testosterone (pg/ml; NR: 0.2–2.2) | 18.7 | 1.7 | 1.1 |
| Androstenedione (ng/dl; NR: 64–245) | 276 | 211 | 159 |
| Dehydroepiandrosterone-S (mg/ml; NR: 650–3,400) | 486 | 829 | — |
| Other hormones | |||
| 17-OH progesterone (ng/ml; NR: 0.5–2.0) | 0.9 | 0.7 | 0.4 |
| Estradiol (pg/ml; NR: 0–47) | 62 | 58 | 13 |
| Luteinizing hormone (IU/l; NR: 16–64) | 2.7 | 14 | 15 |
| Follicle-stimulating hormone (IU/l; NR: 18–153) | 3.1 | 12 | 15 |
| Body composition | |||
| Weight (kg) | 72.6 | 72.0 | 77.7 |
| Body cell mass (kg) | 40.6 | 41.3 | 35.1 |
| Fat mass | |||
| Total body fat (kg) | 16.7 | 16.7 | 23.9 |
| Total body fat (%) | 23.1 | 23.1 | 30.7 |
| Abdominal fat (kg) | 1.7 | 1.6 | 3.4 |
| Insulin sensitivity | |||
| 75-g OGTT | |||
| Blood glucose (mg/dl) | |||
| Fasting | 92 | 95 | 106 |
| 1 h | 180 | 175 | 254 |
| 2 h | 176 | 170 | 236 |
| 3 h | 117 | 134 | 148 |
| AUC | 461 | 460 | 617 |
| Insulin (pmol/l) | |||
| Fasting | 126 | 180 | 132 |
| 1 h | 594 | 492 | 1,320 |
| 2 h | 1,104 | 1,158 | 1,704 |
| 3 h | 732 | 984 | 374 |
| AUC | 2,130 | 2,232 | 3,654 |
| ITT | |||
| Blood glucose (mg/dl) | |||
| 0 min | 90 | 83 | 94 |
| 5 min | 85 | 79 | 93 |
| 10 min | 74 | 75 | 83 |
| 15 min | 65 | 64 | 76 |
| 20 min | 60 | 65 | 72 |
| 25 min | 59 | 64 | 69 |
| 30 min | 58 | 62 | 65 |
| 40 min | 58 | 67 | 68 |
| 50 min | 63 | 70 | 72 |
| 60 min | 68 | 78 | |
| kITT (%/min; NR: 3.84–9.47) | 2.299 | 1.296 | 1.697 |
| Hyperinsulinemic glucose clamp | |||
| Insulin (pmol/l) | |||
| Basal | 149 | 150 | 142 |
| Clamp | 517 | 456 | 514 |
| Free fatty acids (mmol/l) | |||
| Basal | 0.420 | 0.444 | 0.415 |
| Clamp | <0.100 | <0.100 | <0.100 |
| Hepatic glucose production (μmol · kg−1 · min−1) | |||
| Basal | 10.9 | 9.1 | 8.8 |
| Clamp | 5.9 | 1.6 | 1.2 |
| Glucose utilization (μmol · kg−1 · min−1) | |||
| Basal | 10.9 | 9.1 | 8.8 |
| Clamp | 18.4 | 12.4 | 12.8 |
Conversion to SI units: total testosterone: ng/dl × 0.03467 = nmol/l; free testosterone: pg/ml × 34.67 = pmol/l; androstenedione: ng/dl × 0.03492 = pmol/l; dehydroepiandrosterone-S: ng/ml × 0.002714 = μmol/l; 17-OH progesterone: ng/ml × 3.026 = nmol/l; estradiol: pg/ml × 3.671 = pmol/l; glucose: mg/dl × 0.05551 = mmol/l; and insulin: μU/ml × 6 = pmol/l. AUC, area under the curve as calculated with the trapezoidal method; kITT, insulin sensitivity during ITT as calculated by dividing the slope of the blood glucose drop from 5 to 20 min by the average blood glucose in the same period; NR, normal range for age and sex.