Table 2.
Single marker association analyses between sleep duration, short and long sleepers and allelic replication with depressive disorder
| Chr | Gene | SNP | A1/A2 | Gender | Sleep duration (linear model) |
Short sleep (logistic model midrange sleepers as reference) |
Long sleep (logistic model midrange sleepers as reference) |
†Association with depression – disturbed sleep |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MAF | β (95% CI) | P | MAF | OR (95% CI) | P | MAF | OR (95% CI) | P | Group (OR) | Gender | |||||
| 15 | RORA | rs4774388 | A/G | Male | 0.21 | -0.08 (-0.18-0.02) | 0.123 | 0.19 | 1.42 (1.08-1.86) | 0.010 | 0.24 | 0.94 (0.63-1.38) | 0.89 | D+FAT+ (0.61) | Female |
| 12 | TPH2 | rs12229394 | G/A | Male | 0.07 | 0.01 (-0.06-0.09) | 0.697 | 0.08 | 1.28 (1.03-1.59) | 0.024 | 0.10 | 1.33 (1.00-1.76) | 0.041 | D+ (1.28) D+EMA+ (1.40) | Female |
| 12 | TIMELESS | rs2291738 | G/A | Male | 0.11 | -0.03 (-0.10-0.03) | 0.339 | 0.11 | 1.22 (1.00-1.50) | 0.048 | 0.08 | 1.05 (0.80-1.36) | 0.706 | D+FAT+ (1.52) | Female |
| 12 | TIMELESS | rs1082214 | C/T | Male | 0.48 | 0.08 (-0.05-0.21) | 0.238 | 0.47 | 1.23 (0.85-1.78) | 0.266 | 0.48 | 1.61 (1.04-2.50) | 0.026 | D+EMA+ (2.70) D+FAT+ (1.72) | Male |
| X | GRIA3 | rs687577 | C/A | Female | 0.11 | 0.27 (0.16-0.38) | 0.00001* | 0.08 | 0.84 (0.57-1.23) | 0.382 | 0.18 | 1.89 (1.42-2.52) | 0.00001** | D+ (0.70) | Female |
| 17 | SLC6A4 | rs4251417 | G/A | Female | 0.07 | 0.15 (0.01-0.28) | 0.027 | 0.05 | 0.74 (0.46-1.19) | 0.214 | 0.09 | 1.33 (0.92-1.92) | 0.114 | D+ (1.49) D+FAT+ (1.46) | Female |
| 15 | RORA | rs4774370 | T/C | Female | 0.30 | 0.05 (-0.03-0.14) | 0.211 | 0.31 | 0.72 (0.53-0.97) | 0.037 | 0.29 | 1.06 (082-1.38) | 0.616 | D+ (0.75) | Female |
Chr, Chromosome; A1/A2, Major allele/Minor allele; MAF, Minor allele frequency; β, Regression coefficient; OR, Odds ratio. 95% CI, Lower and upper bound confidence interval for β or odds ratio. SNPs (single nucleotide polymorphisms) which showed suggestive association from quantitative and dichotomous analysis (P < 0.05) are marked with bold type.
Permutation-based corrected empirical P = 0.00001, Bonferroni P = 0.000038, P-values adjusted to the number of models (three models in both genders, altogether six models) (Bonferroni corrected P = 0.0052) for association with sleep duration in females.
Permutation-based corrected empirical P = 0.0003, Bonferroni P = 0.00028, P-values adjusted to the number of models (three models in both genders, altogether six models) (Bonferroni corrected P = 0.039) for association with long sleep in females.