TABLE 2.
Gene networks regulated by 5% blueberry ingestion in MDA-MB-231-derived tumors in female nude mice1–3
| Network 1. Score: 43, focus genes: 28. Top functions: inflammatory disease, cancer, cell morphology |
| Symbol (Entrez Gene ID, log ratio) ALOX15 (246, −0.70); ALOX5AP (241, 0.815); ARG1 (383, 0.922); Arginase (group); Collagen Alpha 1 (group); CYBB (1536, 1.262); Eotaxin (group); ESM1 (11082, 0.837); F13A1 (2162, 1.111); Fc Gamma Receptor (group); FCGR1A (2209, −1.044); GBP6 (16335, 1.217); GNRH1 (2796, −0.678); GPRC5B (51704, −0.626); HBA1 (3039, 0.932); HBD (3045, 0.645); HBG1 (3047, 1.208); Hemoglobin (complex); HLA-DOA (3111, −0.755); IFIT5 (24138, 0.707); IFNG (3458, 0.787); IL13 (3596, 0.986); IL13RA2 (3598, −0.674); INHBA (3624, 0.611); KCNJ15 (3772, 0.626); KIR2DS1 (3806, 0.678); LTB4R (1241, −1.118); MHC Class II (complex); NPY2R (4887, −0.748); PKC ALPHA/BETA (family); PLEK (5341, 1.159); QRFP (347148, −0.744); SEPP1 (6414, 1.369); SLAMF1 (6504, −0.773); UBD (10537, −0.813). |
| Network 3. Score: 30, focus genes: 22. Top functions: inflammatory response, cell-to-cell signaling and interaction, hematological system development and function. |
| Symbol (Entrez Gene ID, log ratio) C3AR1 (719, 0.856); CD86 (942, 0.964); CD180 (4064, 0.707); CLEC7A (64581, 0.912); CLIP2 (7461, −0.599);CORO1A (11151, 0.844); Ifn (group); IFN Beta (group); Ifn gamma (complex); IFN TYPE1 (family); IFNA17 (3451, -0.689); IFN Alpha/Beta (family); Iga (complex); IL23 (complex); IL12 (complex); Il12 family (group); Il12 receptor (complex); IL23R (149233, −0.978); LRRFIP1 (9208, −0.641); LSP1 (4046, 0.995) MUC2 (4583, −0.029); NFKB (complex); NFKBID (84807, −0.955); PRF1 (5551, −0.610); PTAFR (5724, −0.768); STAT4 (6775, 0.774); TH2 cytokine (group); TLE6 (79816, −0.888); Tlr (group); TLR7 (51284, 0.910); TNFSF4 (7292, −0.779); UMOD (7369, −0.734); VSNL1 (7447, −0.857); XAF1 (54739, −0.692); XCL1 (6375, −1.209). |
| Network 5. Score: 15, focus genes: 14. Top functions: inflammatory response, cellular movement, hematological system development and function. |
| Symbol (Entrez Gene ID, log ratio) APOBEC3B (9582, 0.220); AZU1 (566, −0.274); BDKRB1 (623, −0.861); CD276 (80381, −0.145); CDA (978, −0.762); CEACAM8 (1088, −0.771); CEACAM3 (1084, −0.158); CFTR (1080, 0.845); CHST4 (10164, 1.238); CLTCL1 (8218, −0.544); CTSF (8722, −0.695); GALNTL4 (8693, 0.087); IL8 (3576, 0.568); IL17B (27190, 0.025); IL17C (27189, −0.094); IL1F6 (27179, −0.416); IL1F9 (56300, −0.575); Importin alpha (group); LPA (4018, −0.611); LPAR2 (9170, −0.614); LPAR3 (23566, −0.247); NANOG (79923, −0.341); NPIP (9284, −1.177); NXF5 (55998, −0.915); NXT1 (29107, 0.067); PDX1 (3651, −0.136); PILRB (29990, −0.704); PMP2 (5375, −0.675); POT1 (25913, 0.702); SNX4 (8723, 0.602); STEAP4 (79689, 0.671); SVIL (6840, −0.470); TNF (7124, 0.565); TNIP3 (79931, 0.284). |
1
Values are based on the log2 ratio (a value of 1 equals a 2-fold change).
2
Positive values are increases and negative values are decreases.
3
Gene ID: see Reference (60).