Table 5.
Quality assessment and summary of findings for studies comparing use of platelet-rich plasma treatments against standard care for acute wounds*
| Quality Assessment | Summary of Findings | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| No of Patients | Effect | ||||||||||
| No of Studies | Design | Quality | Consistency | Directness | Other Modifying Factors | PRP | Controls | Relative (95% CI) | Absolute | Quality | Importance |
| Acute wounds (primary closure) | |||||||||||
| Complete wound healing | |||||||||||
| 1 | RCT | No limitations | No inconsistency | No uncertainty | Short follow-up | 50 | 52 | RD: −0.23 (−0.37 to −0.08) | −23/100 | Mod | Critical |
| Infection | |||||||||||
| 1 | RCT | No limitations | No inconsistency | No uncertainty | Leg infection | 70 | 70 | RD: 0.01 (−0.09 to 0.12) | 1.4/100 | High | Important |
| 1 | Comparative | No serious limitations | No inconsistency | No uncertainty | Leg infection; large N | 560 | 546 | RD: −0.01 (−0.01 to 0) | −5.5/1000 | Mod | Important |
| 2 | Comparative | No serious limitations | No inconsistency | No uncertainty | Superficial infection | 467 | 1028 | RD: −0.02 (−0.06 to 0.01) | −22/1000 | Mod | Important |
| 1 | Comparative | No serious limitations | No inconsistency | No uncertainty | Chest infection; large N; propensity scoring | 571 | 557 | OR: 0.0743 (0.0032-1.7535) | — | Mod | Important |
| 1 | Comparative | No serious limitations | No inconsistency | No uncertainty | Chest infection | 382 | 948 | RD: −0.01 (−0.02 to −0.01) | 14.8/1000 | Mod | Important |
| Pain reduction | |||||||||||
| 3 | RCT | Some serious limitations | Inconsistency between studies | Some uncertainty (overall vs. chest pain) | Small N | 63 | 61 | WMD: −0.75 (−2.38 to 0.89) | −0.75/10 | Very low | Important |
| 1 | RCT | No serious limitations | No inconsistency | Some uncertainty | 50 | 52 | — | No difference | Mod | Important | |
| 1 | RCT | Serious limitations | No inconsistency | Some uncertainty | Dichotomous outcomes | 15 | 15 | RD: 0 (−0.36 to 0.36) | No difference | Very low | Important |
| Wound drainage/exudate | |||||||||||
| 1 | RCT | No serious limitations | No inconsistency | No uncertainty | Small N | 26 | 26 | WMD: 18.6 (36.92 to 0.28) | 18.6 mL | Low | Important |
| 1 | Comparative | No serious limitations | No inconsistency | No uncertainty | Large N; propensity scoring | 571 | 557 | OR: 0.042 | — | Mod | Important |
| 1 | Comparative | No serious limitations | No inconsistency | Some uncertainty | 85 | 80 | RD: −0.13 (−0.21 to −0.04) | −13/100 | Mod | Important | |
| Acute wounds (secondary closure) | |||||||||||
| Complete wound healing | |||||||||||
| 1 | Comparative | Serious limitations | No inconsistency | No uncertainty | Small N | 16 | 16 | RD: 0.31 (−0.02 to 0.64) | 31/100 | Very low | Critical |
| Time to complete wound healing | |||||||||||
| 1 | RCT | No serious limitations | No inconsistency | No uncertainty | Small N | 30 | 22 | — | 6 d | Low | Critical |
| Wound volume reduction | |||||||||||
| 1 | RCT | No serious limitations | No inconsistency | No uncertainty | Small N | 30 | 22 | WMD: 4.9 (3.79-6.01) | 4.9 mL | Mod | Important |
| Area reduction (quotient method) | |||||||||||
| 1 | RCT | No serious limitations | No inconsistency | No uncertainty | Small N | 32 | 27 | WMD: 0.13 (0.08-0.18) | 0.13 cm2 | Mod | Important |
| Pain | |||||||||||
| 1 | RCT | No serious limitations | Some inconsistency | No uncertainty | Small N | 32 | 27 | WMD: −22.2 (−31.16 to −13.28) | −22.2/100 | Low | Important |
*Mod indicates moderate; OR, odds ratio; RCT, randomized controlled trial; RD, risk difference; RR, relative risk; WMD, weighted mean difference.