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Geographical distribution of the T allele frequency at PTPN22 rs2476601 SNP in European RA patients (red) and healthy controls (black) [5], [7]–[9], [16]–[37]. The ‘*’ symbol refers to countries in which a statistical significant different distribution of the PTPN22 T1858 allele among patients and controls was noted. In Tunisia the two existing articles regarding PTPN22 show opposite findings.
