Table 1. Analysis of the association of PTPN22 1858C>T SNP with RA patients and healthy subjects.
| Genotype | ||||||||
| Group | C/C | C/T | T/T | T Allele | HWE (p)1 | OR (95%CIs)2 | Allelic p 3 | |
| Females | RA patients (n = 313) (mean age: 55.7±13.7) | 276 (91.6%) | 36 (11.5%) | 1 (0.3%) | 38 (6.1%) | 1.00 | 1.56 (0.95–2.55) | 0.074 |
| Healthy controls (n = 377) (mean age: 55.5±14.1) | 348 (92.3%) | 28 (7.4%) | 1 (0.3%) | 30 (4.0%) | 0.45 | |||
| Males | RA patients (n = 83) (mean age: 59.7±12.2) | 76 (91.6%) | 7 (8.4%) | 0 (0.0%) | 7 (4.2%) | 1.00 | 1.72 (0.54–5.52) | 0.359 |
| Healthy controls (n = 100) (mean age: 59.4±12.0) | 95 (95.0%) | 5 (5.0%) | 0 (0.0%) | 5 (2.5%) | 1.00 | |||
| All | RA patients (n = 396) (mean age: 56.6±13.4) | 352 (88.9%) | 43 (10.9%) | 1 (0.2%) | 45 (5.7%) | 1.00 | 1.58 (1.01–2.49) | 0.045 |
| Healthy controls (n = 477) (mean age: 56.3±14.0) | 443 (92.9%) | 33 (6.9%) | 1 (0.2%) | 35 (3.7%) | 0.48 | |||
1
HWE: Hardy-Weinberg equilibrium.
2
Odds ratios expressed as carriers of T1858 allele vs. non-carriers considering healthy controls as control group.
3
Fisher's exact test of odds ratios.