Table 1. Liver and adipose tissue contributions to the body weight in wild-type versus mdr1ab-/- mice.
25 weeks | 35 weeks | |||||
Wild-type (n = 6) | Mdr1ab-/- (n = 5) | F | Wild-type (n = 6) | Mdr1ab-/- (n = 5) | F | |
Weight (g) | 31.9±0.6 | 43.9±1.0a | 1.38 | 36.2±1.3 | 44.1±2.0b | 1.22 |
Liver (% of bw) | 4.94±0.28 | 4.87±0.21 | 0.98 | 4.63±0.16 | 4.88±0.21 | 1.05 |
White adipose tissue (% of bw) | ||||||
subcutaneous inguinal | 1.05±0.41 | 2.72±0.13b | 2.58 | 1.35±0.20 | 4.05±0.50a | 2.99 |
perigonadal | 1.86±0.31 | 2.18±0.22 | 1.17 | 2.37±0.27 | 3.55±0.17b | 1.50 |
perirenal | 0.42±0.09 | 0.98±0.02b | 2.32 | 0.91±0.18 | 1.29±0.10 | 1.42 |
mesenteric | 0.75±0.06 | 2.02±0.22a | 2.69 | 1.88±0.19 | 2.26±0.15 | 1.21 |
Total | 4.09±0.65 | 7.91±0.53b | 1.94 | 6.51±0.69 | 11.15±0.46a | 1.71 |
Mice were sacrificed at 25 and 35 weeks of age and discrete fat pads from five anatomical sites were dissected and weighed. WAT refers to white adipose tissue. Total WAT weight represents the sum of the data reported for the four WAT sites considered in the study. Body weight is expressed in gram and tissue weights are expressed as percentage of body weight. F is the ratio of mdr1ab-/- versus wild-type. Results are means ± s.e.m. Statistical relevance of data is assessed by p values.
p<0.05;
p<0.01.