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. 2011 Sep 16;6(9):e23893. doi: 10.1371/journal.pone.0023893

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Urbano et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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CVM cells are visualized using the combination G447.2-GAL4/UAS-CD2 and an anti-CD2 antibody staining. CVM cells from Stgs12 and 13 αPS1 (D, E, M) and αPS2 (G, H, M) mutant embryos are delayed in their migration as compared with wild type cells (A, B, M, yet they still send projections (D, G, arrowhead in magnification in black box) (F, I) In addition, CVM fibers from these mutant embryos detach from the vm at Stg15 (arrowhead in magnification in black box). (J–L) These phenotypes are enhanced in αPS1αPS2 double mutant embryos, phenocopying the defects observed in βPS mutant embryos. (M) Quantification of the CVM migration phenotype in Stg13 embryos of the designated genotypes.