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. 2011 Sep 16;6(9):e24463. doi: 10.1371/journal.pone.0024463

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Granne et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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sST2 (A) and IL-33 (B) were detected by ELISA in maternal side perfusate from an ex vivo of placental perfusion model. Normal (n = 8) and pre-eclampsia (PE) (n = 5) placentas were perfused. sST2 could be identified in media from all of the normal and pre-eclampsia placental perfusions, IL-33 could be identified in one sample from a normal pregnancy. Bars represent median values. C) Placental explants release sST2, secretion was increased by treatment with TNFα and IL-1β (100 ng/ml) and hypoxia-reperfusion injury, and was decreased under hypoxic conditions (n = 3).