Table 2. Sputum cis-eQTL SNPs significantly associated with COPD in the combined COPD GWAS.
Chrom | location | SNP | Affy probe | Gene | eQTL pvalue | FDR-adjusted pvalue | GWAS COPD ORa | GWAS COPD pvaluea | GWAS pvalue (adjusted)b |
15 | 76532762 | rs2656069 | 1555476_at | IREB2 | 0.00030 | 0.042 | 0.75 | 6.8E-06 | 0.023 |
15 | 76681394 | rs1051730 | 206533_at | CHRNA5 | 0.00015 | 0.026 | 1.29 | 2.8E-06 | 0.0093 |
Combined COPD genomewide association study (GWAS) according to Cho et al. [11].
Bonferroni correction for 3309 sputum expression quantitative trait locus (eQTL) single nucleotide polymorphisms (SNPs) tested.