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. 2011 Sep 16;6(9):e24924. doi: 10.1371/journal.pone.0024924

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This is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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WT or mutant Vpr proteins (denoted by the single letter amino acid changes) were delivered (Vpr_v) into Jurkat cells. Virions containing WT Vpr were titrated (md, medium) so that a matched Vpr protein control could be compared to the mutants. (A) Western blot of the Jurkat cells for WT and mutant virion-delivered Vpr (bottom). β-actin is shown as a protein loading control (top). (B) Histograms of cell cycle analysis at 41 hr post-infection show DNA content of PI-stained cells by flow cytometry. All samples represent 10,000 cellular events. G1 and G2/M populations were modeled using the Watson Pragmatic cell cycle model, and the G2,M/G1 ratio in each infection is shown. The data are representative of three experiments.