Table 2.
Relative potencies (REPs) for AHR binding and human Toxic Equivalency Factors (TEFs).
HAH | Chlorination pattern | Beluga REPs for AHR binding | Mouse REPs for AHR binding | Rat REPs for AHR bindinga | 2006 WHO TEFs for humans b |
---|---|---|---|---|---|
TCDD | 2, 3, 7, 8, | 1.00 | 1.00 | 1.0 | 1 |
TCDF | 2, 3, 7, 8, | 0.31 | 0.32 | Not done | 0.1 |
126 | 3, 3′, 4, 4′, 5 | 0.063 | 0.078 | 0.08 | 0.1 |
169 | 3, 3′, 4, 4′, 5, 5′ | 0.014 | 0.011 | Not done | 0.03 |
77 | 3, 3′, 4, 4′ | 0.013 | 0.0038 | 0.01 | 0.0001 |
81 | 3, 4, 4′, 5 | 0.0055 | 0.011 | 0.0004 | 0.0003 |
105 | 2, 3, 3′, 4, 4′ | 0.00018 | 0.00022 | 0.0023 | 0.00003 |
118 | 2, 3′, 4, 4′, 5 | 0.000071 | 0.00011 | 0.0011 | 0.00003 |
156 | 2, 3, 3′, 4, 4′, 5 | 0.00033 | 0.0013 | 0.0014 | 0.00003 |
128 | 2, 2′, 3, 3′, 4, 4′ | 0.00027 | 0.00025 | Not done | no TEF |
calculated from IC50 reported in Bandiera et al., 1982
reported in van den Berg et al., 2006