Skip to main content
. Author manuscript; available in PMC: 2012 Jul 1.
Published in final edited form as: Gene Ther. 2011 May 26;19(1):101–108. doi: 10.1038/gt.2011.76

Figure 4.

Figure 4

The effect of T0TNFSR or T0Z on chronic morphine tolerance. The non-replicating herpes simplex virus (HSV) vector T0TNFSR producing p55 TNFSR, and control vector T0Z were used. Seven days after the vector inoculation, rats received a repeated dose of morphine for 7 days. Thermal latency was tested in the tail flick test (A) and hotplate test (B) at 60 min after each dose of morphine. The MPE of morphine in rats with T0TNFSR was significantly higher than that with T0Z at day 5–7. *p < 0.05, ** p < 0.01 vs T0Z, n=5–6, t test.