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. Author manuscript; available in PMC: 2012 Apr 13.
Published in final edited form as: Oncogene. 2011 May 9;30(41):4243–4260. doi: 10.1038/onc.2011.133

Figure 4. TRK signalling is dysregulated in cylindroma and spiradenoma tissue.

Figure 4

Expression levels of 24526 genes from 32 microdissected tumours were pooled and compared against 10 pooled perilesional controls, and genes that were differentially expressed (p value <0.01) were analysed using Ingenuity pathway analysis. Overexpressed transcripts are shown in red and underexpressed transcripts are shown in green. TRKB (NTRK2) and TRKC (NTRK3), members of the TRK signalling pathway, were overexpressed in tumour tissue compared to control samples. Expression of TRKA (NTRK1) however was reduced. Downstream members such as PI3K and AKT and BCL2 were also over expressed.