TABLE 1. Subject Demographic Information and CERAD Neuropsychological Test Battery.
| Controls (n = 19)a | PS1 Carriers (n = 20)a | t | p | |
|---|---|---|---|---|
| Gender | 16 females | 14 females | ||
| Age (yr) | 34.47 (6.46) | 33.70 (6.01) | 0.38 | 0.70 |
| Range | 24–49 | 25–44 | ||
| Education (yr) | 10.80 (3.28) | 10.70 (2.40) | −0.01 | 0.98 |
| Range | 5–16 | 6–16 | ||
| CERAD tests | ||||
| MMSE/30 | 29.5 (1.0) | 29.7 (0.5) | −0.65 | 0.52 |
| Verbal fluency | 19.26 (5.23) | 18.25 (4.37) | 0.65 | 0.51 |
| Naming/15 | 13.47 (1.50) | 13.80 (1.10) | −0.76 | 0.44 |
| Memory words | ||||
| Reading | 10 (0.00) | 10 (0.00) | ||
| Total correct/30 | 19.21 (3.53) | 19.85 (2.88) | −0.61 | 0.54 |
| Total intrusions | 1.68 (2.45) | 0.90 (1.02) | 1.29 | 0.20 |
| Recall of words | ||||
| Total correct/10 | 7.05 (1.47) | 6.75 (1.47) | 0.61 | 0.54 |
| Total intrusions | 0.32 (0.67) | 0.25 (0.44) | 0.35 | 0.72 |
| Recognition of words | ||||
| Correct “yes”/10 | 9.53 (0.84) | 9.80 (0.41) | −1.28 | 0.21 |
| Correct “no”/10 | 9.95 (0.22) | 10 (0.00) | −1.00 | 0.33 |
| Constructional praxis/11 | 9.84 (0.89) | 9.95 (0.99) | −0.35 | 0.72 |
| Recall of drawings/11 | 9.11 (1.96) | 8.40 (2.25) | 1.04 | 0.30 |
a
Values denoted mean (±standard deviation), except for ranges.
CERAD = Consortium to Establish a Registry for Alzheimer’s Disease; MMSE = Mini-Mental State Examination; PS1 = presenilin-1.