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. Author manuscript; available in PMC: 2012 Sep 1.
Published in final edited form as: Mol Cancer Res. 2011 Jul 20;9(9):1199–1208. doi: 10.1158/1541-7786.MCR-11-0229

Figure 2.

Figure 2

Signaling by chEGFR and chΔEGFR Receptors. Glioma cells U87, LNZ308, and LN428 stably expressing control vector, chEGFR or chΔEGFR were serum starved and then stimulated with 20 ng/ml EGF or 50 nM AP20187 and analyzed at two time points, 5 and 60 min. EGFR downstream signaling was analyzed by immunoblotting with indicated pan- and phospho antibodies; pEGFR(Tyr 845), pAKT(Ser473), pS6K(Thr389), pS6(Ser235/236), and pERK1/2(Thr202/Tyr204).