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Chimeric Receptors Are Inhibited By AG1478. LN428 and LNZ308 glioma cells expressing either chEGFR or chΔEGFR were incubated in media containing no serum (serum starved, ss) or with regular growth medium containing 10% FBS, as indicated. They were left untreated or treated with 10 μM AG1478 for 2h before stimulation with 20 ng/ml EGF or 50 nM AP20187 for another 15 min. Signaling was analyzed by immunoblotting of lysates with the indicated antibodies.
