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. Author manuscript; available in PMC: 2012 Sep 1.
Published in final edited form as: Mol Cancer Res. 2011 Jul 20;9(9):1199–1208. doi: 10.1158/1541-7786.MCR-11-0229

Figure 5.

Figure 5

Dimerization of chΔEGFR Induces Cell Division but Not Migration. (A) LN428 or LNZ308 glioma cells were serum starved and stimulated with 20 ng/ml EGF or 50 nM AP20187 in the presence of 100 μM BrdU for 24h. BrdU incorporation was measured by a colorimetric immunoassay. Data are from three independent experiments (*p < 0.05; **p < 0.01; t-test). (B) A scratch was made in a confluent cell culture of LN428 cells, that were grown in the absence of serum supplemented with 20 ng/ml EGF or 50 nM AP20187 as indicated, and the degree of scratch closure was measured at 24h using a digital photograph and XCAP-Lite software. Graph shows the average ± standard deviation from 4 independent experiments.