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. Author manuscript; available in PMC: 2013 Aug 1.
Published in final edited form as: Neurobiol Aging. 2011 Jun 15;33(8):1609–1623. doi: 10.1016/j.neurobiolaging.2011.05.001

Figure 5. Synaptic transmission in young Tg+ and Tg− mice.

Figure 5

(A) Four overlaid traces showing EPSCs recorded from a 2 month-old Tg− mouse. Paired-pulse protocol with inter-pulse intervals of 25, 50, 100 and 200 ms. (B) Paired-pulse ratios at 2, 4 and 6 months of age. 2 months n = 6 Tg− and 5 Tg+ neurons; 4 months n = 11 Tg− and 13 Tg+ neurons; 6 months n = 8 Tg− and 8 Tg+ neurons. (C) Examples of EPSCs recorded from a 4 month-old Tg+ mouse at −60 and + 40 mV, from which AMPA/NMDA ratios were calculated. (D) AMPA/NMDA ratios in Tg+ and Tg− mice at 2 and 4 months of age. 2 months n = 4 Tg− and 3 Tg+ neurons; 4 months n = 5 Tg− and 6 Tg+ neurons. (E) Miniature EPSCs (mEPSCs) recorded from a 2 month-old Tg+ mouse. (F) mEPSC frequency and amplitude at 2, 3 and 4 months of age. 2 months n = 10 Tg− and 10 Tg+ neurons; 3 months n = 5 Tg− and 6 Tg+ neurons; 4 months n = 7 Tg− and 10 Tg+ neurons.