Table 1.
Electrophysiolgical characteristics of CA1 pyramidal neurons from 2 month-old CRND8 mice.
| Tg− | Tg+ | |
|---|---|---|
| Resting membrane potential (mV) | −63.8 ± 0.4 (n = 59) | −64.4 ± 0.4 (n = 49) |
| Resting input resistance (MΩ) | 124.8 ± 3.7 (n = 59) | 119.4 ± 3.0 (n = 49) |
| Input resistance at −90 mV (MΩ) | 92.4 ± 3.8 (n = 59) | 84.1 ± 2.9 (n = 49) |
| Input resistance at −80 mV (MΩ) | 103.9 ± 3.7 (n = 59) | 97.0 ± 3.0 (n = 49) |
| Input resistance at −70 mV (MΩ) | 120.0 ± 3.7 (n = 59) | 115.7 ± 3.3 (n = 49) |
| Input resistance at −60 mV (MΩ) | 143.1 ± 5.5 (n = 48) | 146.1 ± 5.8 (n = 44) |
| Anomalous rectification (MΩ/nA) | 64.3 ± 4.1 (n = 58) | 68.1 ± 3.8 (n = 49) |
| Sag (steady state/peak ratio) | 0.85 ± 0.007 (n = 33) | 0.84 ± 0.006 (n = 35) |
| Rheobase (pA) | 81.8 ± 4.9 (n = 59) | 82.4 ± 4.8 (n = 49) |
| Current threshold for 10 APs (pA) | 180.5 ± 8.7 (n = 59) | 168.2 ± 6.9 (n = 49) |
| fAHP amplitude (mV) | 7.3 ± 0.92 (n = 59) | 5.7 ± 1.1 (n = 48) |
| ADP amplitude (mV) | 11.8 ± 0.66 (n = 21) | 11.4 ± 0.65 (n = 20) |
| ADP latency (ms) | 2.8 ± 0.1 (n = 21) | 3.0 ± 0.1 (n = 20) |
| ADP decay time (ms) | 19.8 ± 1.3 (n = 21) | 16.6 ± 0.9 (n = 20) |
| Body weight (g) | 28.3 ± 0.8 (n = 20) | 24.7 ± 0.8 (n = 19) |
There was no significant difference in any of the above parameters (Mann Whitney test, P > 0.05), except for body weight, which was significantly smaller for Tg+ than for Tg− mice (P = 0.006).