Table 3.

Multivariate-adjusted^* associations between rate of change in cognitive function by migraine and non-migraine headache status.

Cognitive Test	Coefficient (SE)	p-value
MMSE
Time	0.24 (0.03)	<0.01
Migraine	0.28 (0.21)	0.18
Migraine*Time	−0.01 (0.07)	0.85
Headache	0.33 (0.32)	0.30
Headache*Time	−0.04 (0.10)	0.68
Wechsler
Time	−1.34 (0.09)	<0.01
Migraine	1.09 (1.02)	0.28
Migraine*Time	0.50 (0.22)	0.02
Headache	−1.32 (1.53)	0.39
Headache*Time	0.25 (0.33)	0.44
Trail Making A
Time	0.01 (0.05)	0.79
Migraine	−0.03 (0.24)	0.92
Migraine*Time	0.04 (0.13)	0.76
Headache	0.11 (0.37)	0.76
Headache*Time	−0.04 (0.20)	0.84
Trail Making B
Time	−0.07 (0.04)	0.05
Migraine	0.22 (0.21)	0.29
Migraine*Time	0.02 (0.09)	0.83
Headache	0.38 (0.32)	0.24
Headache*Time	−0.13 (0.14)	0.34
Rey
Time	−1.39 (0.10)	<0.01
Migraine	3.19 (0.82)	<0.01
Migraine*Time	−0.41 (0.27)	0.12
Headache	1.66 (1.24)	0.18
Headache*Time	−0.35 (0.39)	0.36
Raven
Time	−0.11 (0.03)	<0.01
Migraine	0.36 (0.24)	0.14
Migraine*Time	−0.07 (0.08)	0.42
Headache	0.26 (0.36)	0.48
Headache*Time	−0.14 (0.12)	0.22
Benton
Time	−3.78 (0.05)	<0.01
Migraine	−0.13 (0.38)	0.73
Migraine*Time	0.05 (0.13)	0.67
Headache	−1.06 (0.58)	0.07
Headache*Time	0.29 (0.19)	0.14
Finger Tapping
Time	−3.49 (0.21)	<0.01
Migraine	2.53 (1.89)	0.18
Migraine*Time	−0.42 (0.54)	0.43
Headache	1.18 (2.86)	0.68
Headache*Time	0.15 (0.81)	0.85
Word Fluency
Time	0.33 (0.11)	<0.01
Migraine	1.00 (0.93)	0.28
Migraine*Time	0.24 (0.27)	0.36
Headache	1.05 (1.32)	0.42
Headache*Time	−0.19 (0.37)	0.60

^*Adjusted for age (continuous), gender, education (age at which education was completed) and smoking status (never, past and current).

Reference group are those with no history of severe headache.