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Schematic of the role of BDNF in ASM cell proliferation. In human ASM cells, exposure to BDNF results in binding to the high-affinity TrkB receptor that activates the PI3/Akt and ERK1/2 pathways. PI3/Akt further stimulates nuclear translocation of NF-κB, which binds to promoters of genes involved in cellular proliferation. BDNF activation of the low-affinity p75NTR receptor may lead to other, non-proliferative effects in ASM.
