Table 2.
Allelic Association Results for 25 SNPs in the EYS Gene
| SNP | chr6 position | MAF cases n=190 |
MAF controls n=130 |
p | OR (95% CI) |
|---|---|---|---|---|---|
| rs4509103 | 64900230 | 0.03 | 0.03 | 0.88 | 1.08 (0.41–2.82) |
| rs9353681 | 64984651 | 0.19 | 0.26 | 0.03, 0.82* | 0.66 (0.45–0.96) |
| rs12208631 | 65051529 | 0.05 | 0.05 | 0.71 | 0.87 (0.43–1.79) |
| rs11752403 | 65061880 | 0.06 | 0.06 | 0.78 | 1.10 (0.57–2.14) |
| rs10944484 | 65067404 | 0.15 | 0.21 | 0.04, 0.99* | 0.66 (0.44–0.99) |
| rs626316 | 65067582 | 0.31 | 0.23 | 0.02, 0.45* | 1.55 (1.08–2.23) |
| rs17479806 | 65142654 | 0.02 | 0.04 | 0.41 | 0.68 (0.26–1.73) |
| rs644929 | 65168776 | 0.39 | 0.28 | 0.003, 0.09* | 1.67 (1.18–2.34) |
| rs9342288 | 65187046 | 0.38 | 0.25 | 0.001, 0.02* | 1.81 (1.28–2.57) |
| rs7754782 | 65189913 | 0.03 | 0.03 | 0.96 | 0.98 (0.37–2.60) |
| rs9451737 | 65193357 | 0.01 | 0.02 | 0.59 | 0.68 (0.17–2.75) |
| rs1337512 | 65193820 | 0.38 | 0.25 | 0.001, 0.02* | 1.81 (1.28–2.57) |
| rs9451846 | 65219452 | 0.01 | 0.02 | 0.81 | 0.85 (0.23–3.21) |
| rs16895413 | 65224009 | 0.03 | 0.01 | 0.19 | 2.32 (0.63–8.50) |
| rs6934305 | 65225433 | 0.02 | 0.01 | 0.13 | 3.13 (0.67–14.6) |
| rs3857532 | 65233665 | 0.42 | 0.28 | 0.0003, 0.008* | 1.87 (1.33–2.63) |
| rs2993117 | 65243245 | 0.08 | 0.05 | 0.18 | 1.56 (0.81–3.00) |
| rs2993118 | 65243525 | 0.42 | 0.34 | 0.04, 0.95* | 1.42 (1.02–1.97) |
| rs12189763 | 65244987 | 0.29 | 0.28 | 0.81 | 1.04 (0.74–1.48) |
| rs2050621 | 65245338 | 0.27 | 0.24 | 0.44 | 1.16 (0.80–1.66) |
| rs2782295 | 65266980 | 0.28 | 0.30 | 0.50 | 0.89 (0.63–1.25) |
| rs16880108 | 65273495 | 0.28 | 0.25 | 0.48 | 1.14 (0.79–1.63) |
| rs587592 | 65276741 | 0.28 | 0.30 | 0.52 | 0.89 (0.63–1.26) |
| rs17403480 | 65278124 | 0.10 | 0.13 | 0.15 | 0.70 (0.42–1.14) |
| rs10494881 | 65286066 | 0.11 | 0.13 | 0.50 | 0.85 (0.52–1.37) |
MAF: Minor allele frequency, SM: severe statin myopathy, SC: statin-tolerant control group
*
Bonferroni-adjusted p value for 27 SNPs.