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. Author manuscript; available in PMC: 2012 Mar 15.
Published in final edited form as: Nature. 2011 Aug 28;477(7364):295–300. doi: 10.1038/nature10398

Figure 6. A model for lincRNA integration into the molecular circuitry of the cell.

Figure 6

ESC-specific transcription factors (such as Oct4, Sox2, and Nanog) bind to the promoter of a lincRNA gene and drive its transcription. The lincRNA binds to ubiquitous regulatory proteins, giving rise to cell-type specific RNA–protein complexes. Through different combinations of protein interactions, the lincRNA–protein complex can give rise to unique transcriptional programs. Right: A similar process may also work in other cell types with specific transcription factors regulating lincRNAs, creating cell-type–specific RNA–protein complexes and regulating cell-type–specific expression programs.