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. Author manuscript; available in PMC: 2012 Jul 15.
Published in final edited form as: J Org Chem. 2011 Jun 15;76(14):5614–5627. doi: 10.1021/jo200482d

Table 3.

The association rate constant (ka), dissociation rate constant (kd), and equilibrium dissociation constant (Kd) for hybridization of PNA probes with a complementary DNA target.

Oligomer ka (M−1s−1) kd (s−1) Kd (M)
PNA1 4.7×105 13.0×10−4 2.8×10−9
PNA2 9.7×105 4.1×10−4 4.2×10−10
PNA3 6.2×105 1.9×10−4 3.0×10−10
PNA4 6.6×105 0.3×10−4† 4.1×10−11†
PNA5 8.0×105 0.4×10−4† 5.4×10−11†
†

Indicates uncertainty due to the calculated value approaching the limits of detection of the instrument.