Table 3.
Odds ratios (and 95% CI) of having a low PTH level <150, (n=172) vs. target range PTH (150-300, n=288)1
| Variable | Unadjusted | Case-Mix adjusted |
|---|---|---|
| Demographic | ||
| Age (each 10 year ↑) | 1.09 (0.96–1.25) | 1.05 (0.90–1.22) |
| Women (vs. men) | 0.97 (0.66–1.42) | 1.06 (0.69–1.64) |
| Race: Non-Blacks vs. Blacks | 2.33 (1.49–3.70) *** | 2.38 (1.41–2.38) ** |
| Ethnicity: Hispanic (vs. others) | 1.47 (1.00–2.15) * | 1.49 (0.98–2.26) |
| Diabetes mellitus ( vs. no DM) | 1.77 (1.18–2.64) ** | 1.77 (0.99–3.15) |
| Modified Charlson comorbidity score (each 1 unit ↑) | 1.11 (0.98–1.24) | 0.98 (0.83–1.17) |
| Dialysis vintage <6 mo vs. 6-12 mo. | 1.08 (0.58–2.02) | 1.18 (0.60–2.31) |
| Nutritional Status and Body composition | ||
| Malnutrition-inflammation score (each 5 ↑) | 1.68 (1.29–2.18) *** | 1.63 (1.10–2.22) ** |
| Malnutrition-inflammation score ≥5 | 1.62 (1.10–2.40) * | 1.52 (0.96–2.40) |
| Mid-arm muscle circumference (each 1 cm ↑) | 0.97 (0.91–1.01) | 0.95 (0.90–1.00) |
| Near infrared measured body fat (each 1% ↑) | 1.00 (0.98–1.02) | 0.98 (0.95–1.01) |
| Hemodialysis treatment measures | ||
| Dialysis dose (each 1 unit Kt/V sp ↑) | 0.92 (0.48–1.74) | 1.01 (0.99-1.02) |
| nPNA or nPCR (each 0.1 g.kg−1.day−1 ↑) | 1.01 (0.93–1.09) | 0.97 (0.89–1.07) |
| Paricalcitol dose (each 10 mg/mo ↑) | 0.83 (0.73–0.94) ** | 0.85 (0.75–0.98) * |
| Biochemical measurements | ||
| Serum Albumin (each 0.1 g/dl ↓) | 1.08 (1.02–1.12) ** | 1.08 (1.01–1.14) * |
| creatinine (each 1 mg/dl ↓) | 1.14 (1.06–1.20) *** | 1.11 (1.03–1.22) ** |
| Total iron binding capacity (each 10 mg/dL ↓) | 1.09 (1.03–1.14) ** | 1.09 (1.03–1.16) ** |
| calcium (each 1 mg/dl ↑) | 1.04 (0.77–1.39) | 1.13 (0.81–1.58) |
| phosphorus (each 1 mg/dl ↓) | 1.39 (1.19–1.64) *** | 1.41 (1.18–1.67) *** |
| phosphorus <3.5 vs. (≥3.5 mg/dl) | 2.75 (1.16-6.49) * | 3.13 (1.24-7.94) * |
| Alkaline phosphasae (each 10 mg/dl ↑) | 0.99 (0.96–1.03) | 1.00 (0.99–1.00) |
| TNF-α ≥6 (vs. <6 pg/ml) | 1.56 (1.06-2.30) * | 1.64 (1.07-2.51) * |
| CRP ≥15 (vs. <15 mg/l) | 1.99 (1.02-3.86) * | 1.85 (0.90-3.77) |
| IL-6 ≥ 5 (vs. <5 pg/ml) | 1.44 (0.95-2.18) | 1.50 (0.95-2.37) |
| Blood hemoglobin (each 1 g/dl ↑) | 0.87 (0.71–1.07) | 0.86 (0.69–1.08) |
| WBC (each 1000 cell/μl ↑) | 1.00 (0.91–1.10) | 0.96 (0.86–1.06) |
| lymphocyte (each 1 % ↑) | 0.96 (0.93–0.99) ** | 0.97 (0.95–1.0) |
CRP, C-reactive protein; IL-6, Interleukin 6; TNF-α, Tumor necrosis factor-α
Case-mix variables: age, gender, race/ethnicity, diabetes, log vintage, primary insurance (medicare), modified Charlson comorbidity score, dialysis dose (kt/v)
*
p=0.01 to 0.05
**
p=0.001 to 0.01
***
p<0.001