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. Author manuscript; available in PMC: 2011 Sep 18.
Published in final edited form as: Mol Cell. 2011 Apr 8;42(1):9–22. doi: 10.1016/j.molcel.2011.03.004

Figure 2.

Figure 2

CDK/Src-like inactive conformation. (A) The activation mechanisms of the Src family of kinases and cyclin-dependent kinases (CDKs). When not bound to SH2 and SH3 domains, Src kinases adopt an active conformation. In contrast, CDKs are inactive when not bound to their regulators cyclins. Activation of CDKs requires cyclin binding. (B) Crystal structures of the Hck kinase (PDB ID: 1QCF) in the CDK/Src-like inactive conformation, Lck kinase (PDB ID: 3LCK) in the active conformation and the Hck kinase (PDB ID: 2HCK) in the alternate CDK/Src-like inactive conformation. For clarity the SH2 and SH3 domains are not shown in the inactive structures. The insets underneath the structures selectively display the activation loop, helix αC, P-loop and the selected residues to highlight major conformational changes between different states.