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Potential targets for selected novel therapies for treatment resistant asthma. The figure summarizes targets for a selection of therapies that are recently licensed or under clinical development for patients with severe treatment resistant asthma. Abbreviations: CRTH2, chemoattractant receptor-homologous molecule expressed on Th2 cells; FLAP, lipoxygenase-activating protein; IL-, interleukin-; PPAR, proliferator-activated receptor; PDE, phosphodiesterase; PGD2, prostaglandin D2.
